My expertise in genomics is strongly oriented toward industrial biotechnology and applied research. I have worked extensively on microbial and plant genomics to identify and optimize genes, pathways, and regulatory mechanisms that are critical for bioenergy, biorefinery, and sustainable bioprocess development. My experience includes genome sequencing, annotation, and metabolic pathway analysis, with a focus on harnessing microbial diversity for industrially relevant enzymes, biofuels, and value-added bioproducts.
I have applied functional genomics and systems biology to
improve microbial strains and processes, integrating transcriptomic, proteomic,
and metabolomic data to enhance productivity and efficiency. In addition, I
have contributed to genome-based metabolic modeling and gene-editing approaches
for strain engineering, enabling more robust and high-yield production systems.
Another key area of my expertise is metagenomics, where I
explore microbial communities in natural and engineered environments to
discover novel enzymes and biocatalysts with industrial potential. This work
supports applications in waste valorization, circular bioeconomy, and renewable
energy.
Overall, my genomics research bridges fundamental
discoveries with industrial applications, providing practical solutions for
bioprocess innovation, bioenergy production, and sustainable technologies that
contribute directly to the growth of the bio-based economy.
The most exciting aspect of the Genomics in Context
funding call is its emphasis on linking genomic science to pressing societal
and health challenges. For me, antimicrobial resistance (AMR) in children in
Nepal represents a critical area where genomics can provide transformative
insights. Childhood infections remain a leading cause of morbidity and
mortality in Nepal, and the rising burden of AMR severely undermines treatment
outcomes. However, systematic genomic surveillance and contextual understanding
of resistance determinants in this vulnerable population remain very limited.
I am particularly interested in pursuing research that
combines whole-genome sequencing and metagenomic approaches to characterize
resistant pathogens and their transmission dynamics in community and hospital
settings. This includes identifying resistance genes, plasmid-mediated
transfer, and the role of the gut microbiome in shaping resistance patterns
among children. Equally important is integrating these genomic insights with
social, behavioral, and environmental data to understand how antibiotic use, healthcare
practices, and sanitation conditions influence AMR emergence and spread.
Through this funding opportunity, I aim to develop
genomic-informed surveillance strategies tailored to Nepal’s context,
ultimately contributing to evidence-based policies for rational antibiotic use,
targeted interventions in pediatric care, and strengthening of Nepal’s public
health capacity to address AMR.
Abstract 1: Policy Relevance
Antimicrobial resistance (AMR) is an urgent child health
challenge in Nepal, where high antibiotic use and limited surveillance
contribute to rising resistance. Genomics can provide actionable evidence by
identifying resistance genes and transmission pathways. This information will
support policymakers in strengthening Nepal’s National Action Plan on AMR,
guiding antibiotic stewardship, and shaping child-focused interventions.
Abstract 2: Public Health Programs
Children in Nepal are increasingly vulnerable to infections
that no longer respond to common antibiotics. By combining genomic research
with health system data, we can design targeted surveillance programs and
community-level awareness campaigns. Partnerships with NGOs and government
agencies will ensure that findings translate into improved prescribing
practices, sanitation initiatives, and child health programs.
Abstract 3: Global and Local Impact
Addressing AMR in children requires both local solutions and
alignment with global strategies. Genomic studies of resistant pathogens in
Nepal will generate evidence critical for resource allocation, pediatric care
guidelines, and regional collaboration. NGOs and policy partners play a vital
role in ensuring these insights are integrated into sustainable public health
policies that protect children.
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