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 My expertise in genomics is strongly oriented toward industrial biotechnology and applied research. I have worked extensively on microbial and plant genomics to identify and optimize genes, pathways, and regulatory mechanisms that are critical for bioenergy, biorefinery, and sustainable bioprocess development. My experience includes genome sequencing, annotation, and metabolic pathway analysis, with a focus on harnessing microbial diversity for industrially relevant enzymes, biofuels, and value-added bioproducts.

I have applied functional genomics and systems biology to improve microbial strains and processes, integrating transcriptomic, proteomic, and metabolomic data to enhance productivity and efficiency. In addition, I have contributed to genome-based metabolic modeling and gene-editing approaches for strain engineering, enabling more robust and high-yield production systems.

Another key area of my expertise is metagenomics, where I explore microbial communities in natural and engineered environments to discover novel enzymes and biocatalysts with industrial potential. This work supports applications in waste valorization, circular bioeconomy, and renewable energy.

Overall, my genomics research bridges fundamental discoveries with industrial applications, providing practical solutions for bioprocess innovation, bioenergy production, and sustainable technologies that contribute directly to the growth of the bio-based economy.

 

 

The most exciting aspect of the Genomics in Context funding call is its emphasis on linking genomic science to pressing societal and health challenges. For me, antimicrobial resistance (AMR) in children in Nepal represents a critical area where genomics can provide transformative insights. Childhood infections remain a leading cause of morbidity and mortality in Nepal, and the rising burden of AMR severely undermines treatment outcomes. However, systematic genomic surveillance and contextual understanding of resistance determinants in this vulnerable population remain very limited.

I am particularly interested in pursuing research that combines whole-genome sequencing and metagenomic approaches to characterize resistant pathogens and their transmission dynamics in community and hospital settings. This includes identifying resistance genes, plasmid-mediated transfer, and the role of the gut microbiome in shaping resistance patterns among children. Equally important is integrating these genomic insights with social, behavioral, and environmental data to understand how antibiotic use, healthcare practices, and sanitation conditions influence AMR emergence and spread.

Through this funding opportunity, I aim to develop genomic-informed surveillance strategies tailored to Nepal’s context, ultimately contributing to evidence-based policies for rational antibiotic use, targeted interventions in pediatric care, and strengthening of Nepal’s public health capacity to address AMR.

 

Abstract 1: Policy Relevance

Antimicrobial resistance (AMR) is an urgent child health challenge in Nepal, where high antibiotic use and limited surveillance contribute to rising resistance. Genomics can provide actionable evidence by identifying resistance genes and transmission pathways. This information will support policymakers in strengthening Nepal’s National Action Plan on AMR, guiding antibiotic stewardship, and shaping child-focused interventions.

Abstract 2: Public Health Programs

Children in Nepal are increasingly vulnerable to infections that no longer respond to common antibiotics. By combining genomic research with health system data, we can design targeted surveillance programs and community-level awareness campaigns. Partnerships with NGOs and government agencies will ensure that findings translate into improved prescribing practices, sanitation initiatives, and child health programs.

Abstract 3: Global and Local Impact

Addressing AMR in children requires both local solutions and alignment with global strategies. Genomic studies of resistant pathogens in Nepal will generate evidence critical for resource allocation, pediatric care guidelines, and regional collaboration. NGOs and policy partners play a vital role in ensuring these insights are integrated into sustainable public health policies that protect children.

 

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Ashok Pandey

  Ashok Pandey , MPH, is an Associate Research Fellow at the Policy Research Institute (PRI) —Nepal’s premier government think tank under the Office of the Prime Minister and Council of Ministers. Specializing in Medical and Health Sciences / Epidemiology and Public Health , his expertise spans health governance, policy research, non-communicable diseases, and health systems research . According to the AD Scientific Index (ID: 6347499) , Dr. Pandey ranks 349,313 globally and 63rd in Nepal , and holds the #1 position within PRI in his discipline. He has an H-index of 25 (total) and 24 in the last five years , reflecting a high proportion of recent impactful work (last 5 years/total ratio: 0.96 ). With nearly 200 publications , over 12,500 citations , and 127,000 reads , Dr. Pandey’s research contributions demonstrate both academic rigor and applied policy relevance. He previously served as Senior Research Officer at the Nepal Health Research Council and is Executive Directo...
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